Welcome to the TOPS Website

Welcome to the TOPS (Timing of Primary Surgery for Cleft Palate) Website

TOPS is an international randomised control trial which aims to investigate the impact of the timing of surgery for cleft palate repair on speech development.

This website can be used to access information about the TOPS trial including updates on trial status.

The trial is sponsored by the University of Manchester and funded by the National Institute of Health, National Institute for Dental and Craniofacial Research (NIH-NIDCR). TOPS is coordinated by the University of Manchester (Administrative Centre) and the Medicines for Children Research Network Clinical Trials Unit at the University of Liverpool (Data Coordinating Centre).

Recruitment status:
558 infants have been recruited to the trial. Recruitment closed in July 2015 and participants are continuing in follow up for the trial.